Microinjection System MIS
A micro-valve plug-in for precise microinjection of liquids onto samples in the low-vacuum SEM, down to roughly 100 µm droplets.
Liquid or gas, drop by drop#
The MIS-EM places liquids onto a sample inside a low-vacuum SEM, one controlled drop at a time. A fine pipette — 150 µm outer diameter tapering to a 50 µm bore — puts down droplets as small as 100 µm when tested with water, smaller or larger depending on the fluid’s viscosity. The micro-valve behind it is what makes the volume repeatable: it opens and closes on command, so the manipulator can position the tip over the point of interest and the valve does the rest. Non-condensing gases work through the same valve, not just liquids.
Six fields, one microvalve#
That pairing of controlled microinjection with precision manipulation has carried the MIS-EM into work well outside a typical materials lab — sugar-coating reactions in food science, fibre swelling in textiles, chemical reactions in pharma formulation, cement testing in construction, regenerative-medicine work in biology, corrosion studies in metallurgy. Your existing micromanipulator system can be quickly and easily upgraded for use with the MIS-EM, so the same manipulator that probes and grips can also deliver fluid.
Gallery
A droplet forming at the pipette tip, positioned by the manipulator inside the chamber.
Technical data
Micro-valve
- Length
- 31.4 mm
- Diameter
- 5.6 mm
- Weight
- 3 g
Fluidics
- Inlet inner diameter
- 0.6 mm
- Outlet outer diameter
- 0.5 mm
- Outlet inner diameter
- 0.25 mm
- Injection pipette outer diameter
- 150 µm
- Injection pipette inner diameter
- 50 µm
- Smallest drop size
- 100 µm (with water; varies with viscosity)
Environment & materials
- Temperature range
- 273 K – 353 K
- Wetted materials
- EPDM seal, PEEK, PPS, glass, polyoxymethylene, stainless steel, epoxy
See it run
Advantages
Precise microinjection
- Micro-valve places droplets as small as 100 µm (measured with water; varies with viscosity)
- Fine pipette — 150 µm outer diameter, 50 µm inner diameter
- Also handles non-condensing gases, not just liquids
Manipulator-guided, chamber-wide reach
- Manipulator positions the pipette over the exact point of interest, then the valve dispenses
- Runs in low-vacuum SEM, from sugar-coating trials to metal corrosion studies
Plug-in design
- Retrofits to an existing MM3A-EM micromanipulator
- Quick, easy installation
Related products & accessories
MM3A-EM
The industry-standard spherical micromanipulator — the platform every Kleindiek plug-in tool attaches to, with 3000+ units in the field.
View product
Gas Injection System GIS
A gas-injection plug-in that meters precursors and gases into the SEM chamber in precise doses, through a proportional valve driven by a Nanomotor®.
View productTalk to an application engineer
Tell us your sample and your microscope — we’ll walk you through the workflow and route you to the right regional team.